{"id":7657,"date":"2026-04-10T10:57:17","date_gmt":"2026-04-10T10:57:17","guid":{"rendered":"https:\/\/fakt24.biz.ua\/?p=7657"},"modified":"2026-04-10T10:57:17","modified_gmt":"2026-04-10T10:57:17","slug":"varovani-toto-jsou-znamky-toho-ze-se-jedna-o-zobrazit-vice","status":"publish","type":"post","link":"https:\/\/fakt24.biz.ua\/?p=7657","title":{"rendered":"VAROV\u00c1N\u00cd: Toto jsou zn\u00e1mky toho, \u017ee se jedn\u00e1 o\u2026 Zobrazit v\u00edce"},"content":{"rendered":"\n

Vz\u00e1cn\u00e1 reakce: Kdy\u017e inhal\u00e1tor vyvol\u00e1 sladk\u00fd syndrom<\/p>\n\n\n\n

Co za\u010dalo jako rutinn\u00ed \u00faprava inhal\u00e1toru pacienta s CHOPN, se rychle rozvinulo v matouc\u00ed l\u00e9ka\u0159skou z\u00e1hadu. B\u011bhem pouh\u00fdch dvou dn\u016f se u 55let\u00e9 \u017eeny objevily na obli\u010deji a krku intenzivn\u011b bolestiv\u00e9, jasn\u011b \u010derven\u00e9 skvrny doprov\u00e1zen\u00e9 m\u00edrnou hore\u010dkou.<\/p>\n\n\n\n

Zat\u00edmco viditeln\u00e9 p\u0159\u00edznaky rychle ustoupily, v\u00fdsledky biopsie odhalily ne\u010dekanou diagn\u00f3zu \u2013 Sweet\u016fv syndrom, vz\u00e1cn\u00e9 imunitn\u011b podm\u00edn\u011bn\u00e9 ko\u017en\u00ed onemocn\u011bn\u00ed.<\/p>\n\n\n\n

Tento neobvykl\u00fd p\u0159\u00edpad m\u016f\u017ee znamenat prvn\u00ed spojen\u00ed inhala\u010dn\u00edho l\u00e9ku s t\u00edmto onemocn\u011bn\u00edm, co\u017e vyvol\u00e1v\u00e1 nov\u00e9 ot\u00e1zky ohledn\u011b skryt\u00fdch rizik b\u011b\u017en\u011b p\u0159edepisovan\u00fdch l\u00e9\u010debn\u00fdch postup\u016f.<\/p>\n\n\n\n

Pacientka s anamn\u00e9zou hypertenze a CHOPN byla po l\u00e9ta stabiln\u00ed na inhal\u00e1toru s enalaprilem a formoterolem. Vzhledem k zhor\u0161uj\u00edc\u00ed se plicn\u00ed funkci j\u00ed plicn\u00ed l\u00e9ka\u0159 zm\u011bnil inhal\u00e1tor na kombinaci indakaterolu a glykopyrronia. Pouh\u00fdch 48 hodin po zah\u00e1jen\u00ed u\u017e\u00edv\u00e1n\u00ed nov\u00e9ho inhal\u00e1toru se u n\u00ed objevily bolestiv\u00e9 erytemat\u00f3zn\u00ed plaky na obli\u010deji a krku a m\u00edrn\u00e1 hore\u010dka. Pop\u0159ela pou\u017e\u00edv\u00e1n\u00ed nov\u00fdch kosmetick\u00fdch p\u0159\u00edpravk\u016f, zm\u011bny ve strav\u011b nebo p\u0159\u00edznaky nachlazen\u00ed, ale zm\u00ednila se o ned\u00e1vn\u00e9m slun\u011bn\u00ed s vhodnou ochranou.<\/p>\n\n\n\n

Pot\u00e9, co byla pacientka nal\u00e9hav\u011b odesl\u00e1na na dermatologickou konzultaci, inhal\u00e1tor byl vysazen. Krevn\u00ed testy vylou\u010dily infekce a autoimunitn\u00ed markery, zat\u00edmco biopsie k\u016f\u017ee potvrdila Sweetov syndrom. Byly j\u00ed p\u0159edeps\u00e1ny peror\u00e1ln\u00ed kortikosteroidy, kter\u00e9 vedly k rychl\u00e9mu zlep\u0161en\u00ed symptom\u016f b\u011bhem dvou dn\u016f.<\/p>\n\n\n\n

Sweetov syndrom, zn\u00e1m\u00fd tak\u00e9 jako akutn\u00ed febriln\u00ed neutrofiln\u00ed dermat\u00f3za, je charakterizov\u00e1n n\u00e1hl\u00fdm n\u00e1stupem bolestiv\u00fdch, \u010derven\u00fdch papul\u00ed nebo plak\u016f \u2013 \u010dasto asymetrick\u00fdch \u2013 postihuj\u00edc\u00edch p\u0159edev\u0161\u00edm obli\u010dej, krk, horn\u00ed \u010d\u00e1st trupu a ruce. Obvykle se projevuje syst\u00e9mov\u00fdmi p\u0159\u00edznaky, jako je hore\u010dka a zv\u00fd\u0161en\u00e9 mno\u017estv\u00ed b\u00edl\u00fdch krvinek.<\/p>\n\n\n\n

P\u0159esto\u017ee p\u0159esn\u00e1 p\u0159\u00ed\u010dina Sweetova syndromu z\u016fst\u00e1v\u00e1 nejasn\u00e1, p\u0159edpokl\u00e1d\u00e1 se, \u017ee pramen\u00ed z imunitn\u00edch reakc\u00ed vyvolan\u00fdch cytokiny, kter\u00e9 jsou vyvol\u00e1ny infekcemi, rakovinou nebo ur\u010dit\u00fdmi l\u00e9ky \u2013 v\u010detn\u011b antibiotik, antiepileptik a vakc\u00edn. L\u00e9\u010dba kortikosteroidy obvykle p\u0159in\u00e1\u0161\u00ed rychlou \u00falevu.<\/p>\n\n\n\n

Tento p\u0159\u00edpad vynik\u00e1 t\u00edm, \u017ee inhala\u010dn\u00ed terapie nebyly dosud nikdy zdokumentov\u00e1ny jako spou\u0161t\u011b\u010d. Diferenci\u00e1ln\u00ed diagn\u00f3zy, jako je kontaktn\u00ed dermatitida, lupus nebo kop\u0159ivka, byly pe\u010dliv\u011b vylou\u010deny.<\/p>\n\n\n\n

Vz\u00e1cnost Sweetova syndromu a jeho potenci\u00e1ln\u00ed souvislost se z\u00e1va\u017en\u00fdmi syst\u00e9mov\u00fdmi onemocn\u011bn\u00edmi znamenaj\u00ed, \u017ee je p\u0159i po\u010d\u00e1te\u010dn\u00edch diagn\u00f3z\u00e1ch \u010dasto p\u0159ehl\u00ed\u017een. Tento p\u0159\u00edpad zd\u016fraz\u0148uje kl\u00ed\u010dovou roli, kterou hraj\u00ed poskytovatel\u00e9 prim\u00e1rn\u00ed p\u00e9\u010de p\u0159i identifikaci neobvykl\u00fdch reakc\u00ed spojen\u00fdch se zm\u011bnami l\u00e9k\u016f a zaji\u0161t\u011bn\u00ed v\u010dasn\u00e9ho odesl\u00e1n\u00ed k l\u00e9ka\u0159i a l\u00e9\u010dby.<\/p>\n\n\n\n

Tento p\u0159\u00edpad slou\u017e\u00ed jako p\u0159ipom\u00ednka toho, \u017ee i zn\u00e1m\u00e9 l\u00e9ky \u2013 jako jsou inhal\u00e1tory \u2013 mohou ob\u010das vyvolat vz\u00e1cn\u00e9, z\u00e1va\u017en\u00e9 imunitn\u00ed reakce. Pro l\u00e9ka\u0159e je z\u00e1sadn\u00ed sledovat n\u00e1hl\u00e9 zm\u011bny na k\u016f\u017ei po \u00faprav\u011b l\u00e9k\u016f. Rozpozn\u00e1n\u00ed atypick\u00fdch p\u0159\u00ed\u010din Sweetova syndromu roz\u0161i\u0159uje diagnostick\u00e9 pov\u011bdom\u00ed a m\u016f\u017ee v\u00e9st k rychlej\u0161\u00edm a \u017eivot m\u011bn\u00edc\u00edm intervenc\u00edm.<\/p>\n\n\n\n

\"\"\/<\/figure>\n","protected":false},"excerpt":{"rendered":"Vz\u00e1cn\u00e1 reakce: Kdy\u017e inhal\u00e1tor vyvol\u00e1 sladk\u00fd syndrom Co za\u010dalo jako rutinn\u00ed \u00faprava inhal\u00e1toru pacienta s CHOPN, se rychle rozvinulo v matouc\u00ed l\u00e9ka\u0159skou z\u00e1hadu. \n [...]<\/a>","protected":false},"author":1,"featured_media":7658,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-7657","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"_links":{"self":[{"href":"https:\/\/fakt24.biz.ua\/index.php?rest_route=\/wp\/v2\/posts\/7657","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fakt24.biz.ua\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/fakt24.biz.ua\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/fakt24.biz.ua\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/fakt24.biz.ua\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=7657"}],"version-history":[{"count":1,"href":"https:\/\/fakt24.biz.ua\/index.php?rest_route=\/wp\/v2\/posts\/7657\/revisions"}],"predecessor-version":[{"id":7659,"href":"https:\/\/fakt24.biz.ua\/index.php?rest_route=\/wp\/v2\/posts\/7657\/revisions\/7659"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/fakt24.biz.ua\/index.php?rest_route=\/wp\/v2\/media\/7658"}],"wp:attachment":[{"href":"https:\/\/fakt24.biz.ua\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=7657"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/fakt24.biz.ua\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=7657"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/fakt24.biz.ua\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=7657"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}