{"id":6325,"date":"2026-03-18T17:31:35","date_gmt":"2026-03-18T17:31:35","guid":{"rendered":"https:\/\/fakt24.biz.ua\/?p=6325"},"modified":"2026-03-18T17:31:35","modified_gmt":"2026-03-18T17:31:35","slug":"biotechnologie-tato-spolecnost-tvrdi-ze-prodlouzila-zivot-mysi-preprogramovanim-jejich-bunek-2","status":"publish","type":"post","link":"https:\/\/fakt24.biz.ua\/?p=6325","title":{"rendered":"Biotechnologie: Tato spole\u010dnost tvrd\u00ed, \u017ee prodlou\u017eila \u017eivot my\u0161\u00ed p\u0159eprogramov\u00e1n\u00edm jejich bun\u011bk."},"content":{"rendered":"\n

Americk\u00fd startup tvrd\u00ed, \u017ee se mu poda\u0159ilo \u00fasp\u011b\u0161n\u011b \u201ep\u0159eprogramovat\u201c bu\u0148ky st\u00e1rnouc\u00edch my\u0161\u00ed, co\u017e jim umo\u017enilo \u017e\u00edt d\u00e9le.<\/p>\n\n\n\n

Tento v\u00fdsledek byl p\u0159edv\u00eddateln\u00fd a nazna\u010duje, \u017ee bychom jednoho dne mohli b\u00fdt schopni pomoc\u00ed t\u00e9to metody prodlou\u017eit lidsk\u00fd \u017eivot.<\/p>\n\n\n\n

Mal\u00e1 biotechnologick\u00e1 spole\u010dnost  s n\u00e1zvem Rejuvenate Bio<\/a>  uv\u00e1d\u00ed, \u017ee pou\u017eila technologii zvanou \u201ebun\u011b\u010dn\u00e9 reprogramov\u00e1n\u00ed\u201c k omlazen\u00ed star\u00fdch my\u0161\u00ed a prodlou\u017een\u00ed jejich \u017eivota.<\/p>\n\n\n\n

Tento v\u00fdsledek nazna\u010duje, \u017ee jednoho dne bude mo\u017en\u00e9 odd\u00e1lit biologick\u00e9 hodiny star\u0161\u00edch lid\u00ed pomoc\u00ed injekce, \u010d\u00edm\u017e je doslova oml\u00e1dne.<\/p>\n\n\n\n

Toto tvrzen\u00ed o prodlou\u017een\u00e9 d\u00e9lce \u017eivota hlodavc\u016f u\u017e\u00edvaj\u00edc\u00edch Rejuvenate Bio bylo u\u010din\u011bno v p\u0159edb\u011b\u017en\u00e9m \u010dl\u00e1nku publikovan\u00e9m na BioRxiv a nepro\u0161lo recenzn\u00edm \u0159\u00edzen\u00edm.<\/p>\n\n\n\n

Technika bun\u011b\u010dn\u00e9ho reprogramov\u00e1n\u00ed, jej\u00edm\u017e c\u00edlem je obnovit mladistv\u00fd stav bun\u011bk, p\u0159il\u00e1kala  investice v \u0159\u00e1du stovek milion\u016f dolar\u016f<\/a>  . V\u011bdci ji\u017e prok\u00e1zali jej\u00ed \u00fa\u010dinnost na jednotliv\u00fdch bu\u0148k\u00e1ch v laborato\u0159i a v sou\u010dasn\u00e9 dob\u011b se sna\u017e\u00ed zjistit, zda omlazuj\u00edc\u00ed \u00fa\u010dinek funguje i u \u017eiv\u00fdch zv\u00ed\u0159at.<\/p>\n\n\n\n

\u010cl\u00e1nek z Rejuvenate Bio poskytuje tolik pot\u0159ebn\u00e9 d\u016fkazy o tom, \u017ee tato metoda skute\u010dn\u011b m\u016f\u017ee prodlou\u017eit \u017eivot zv\u00ed\u0159at.<\/p>\n\n\n\n

\"Je<\/a><\/figure>\n\n\n\n

Noah Davidsohn, hlavn\u00ed v\u011bdeck\u00fd pracovn\u00edk spole\u010dnosti Rejuvenate Bio, prozradil, \u017ee spole\u010dnost pou\u017eila genovou terapii a zavedla t\u0159i siln\u00e9 reprogramovac\u00ed geny do my\u0161\u00ed, jejich\u017e v\u011bk odpov\u00eddal v\u011bku 77let\u00e9ho \u010dlov\u011bka.<\/p>\n\n\n\n

Podle spole\u010dnosti se s\u00eddlem v San Diegu se jejich zb\u00fdvaj\u00edc\u00ed d\u00e9lka \u017eivota po l\u00e9\u010db\u011b zdvojn\u00e1sobila. L\u00e9\u010den\u00e9 my\u0161i \u017eily v pr\u016fm\u011bru o 18 t\u00fddn\u016f d\u00e9le, zat\u00edmco kontroln\u00ed my\u0161i uhynuly do dev\u00edti t\u00fddn\u016f. Celkov\u011b l\u00e9\u010den\u00e9 my\u0161i \u017eily asi o 7 % d\u00e9le.<\/p>\n\n\n\n

P\u0159esto\u017ee je prodlou\u017een\u00ed d\u00e9lky \u017eivota m\u00edrn\u00e9, spole\u010dnost tvrd\u00ed, \u017ee tyto studie prokazuj\u00ed zvr\u00e1cen\u00ed st\u00e1rnut\u00ed u zv\u00ed\u0159at. \u201eJe to v\u00fdkonn\u00e1 technologie a toto je zt\u011blesn\u011bn\u00edm tohoto konceptu,\u201c \u0159\u00edk\u00e1 nad\u0161en\u011b Noah Davidsohn. \u201eCht\u011bl jsem uk\u00e1zat, \u017ee je to skute\u010dn\u011b n\u011bco, co lze aplikovat na st\u00e1rnouc\u00ed populaci.\u201c<\/p>\n\n\n\n

V\u011bdci nez\u00e1visl\u00ed na spole\u010dnosti ozna\u010dili studii za vzru\u0161uj\u00edc\u00ed krok, ale varovali, \u017ee omlazen\u00ed cel\u00e9ho t\u011bla pomoc\u00ed genov\u00e9 terapie z\u016fst\u00e1v\u00e1 \u0161patn\u011b pochopen\u00fdm konceptem s obrovsk\u00fdmi riziky. \u201eJe to kr\u00e1sn\u00e9 intelektu\u00e1ln\u00ed cvi\u010den\u00ed, ale byl bych velmi opatrn\u00fd, pokud jde o prov\u00e1d\u011bn\u00ed n\u011b\u010deho podobn\u00e9ho u lid\u00ed,\u201c \u0159ekl Vittorio Sebastiano, profesor na Stanfordsk\u00e9 univerzit\u011b.<\/p>\n\n\n\n

Jedn\u00edm z nebezpe\u010d\u00ed je, \u017ee tento siln\u00fd programovac\u00ed proces m\u016f\u017ee zp\u016fsobit rakovinu. Tento efekt je \u010dasto pozorov\u00e1n u my\u0161\u00ed.<\/p>\n\n\n\n

Mo\u017enost, \u017ee by reprogramov\u00e1n\u00ed mohlo b\u00fdt zdrojem ml\u00e1d\u00ed, v\u0161ak vedla k prudk\u00e9mu n\u00e1r\u016fstu v\u00fdzkumu a investic. Jedna spole\u010dnost, Altos Labs, tvrd\u00ed, \u017ee z\u00edskala p\u0159es 3 miliardy dolar\u016f.<\/p>\n\n\n\n

V laborato\u0159i reprogramov\u00e1n\u00ed zahrnuje vystaven\u00ed jednotliv\u00fdch bun\u011bk souboru t\u0159\u00ed nebo \u010dty\u0159 protein\u016f, kter\u00e9 jsou typicky aktivn\u00ed v ran\u00fdch embry\u00edch. N\u011bkolik dn\u00ed po pod\u00e1n\u00ed l\u00e9ku se i star\u00e9 bu\u0148ky transformuj\u00ed na mlad\u00e9 kmenov\u00e9 bu\u0148ky.<\/p>\n\n\n\n

V roce 2012 byla biologovi ud\u011blena Nobelova cena za medic\u00ednu za pr\u00e1ci na p\u0159eprogramov\u00e1n\u00ed dosp\u011bl\u00fdch bun\u011bk.<\/h2>\n\n\n\n

Objev receptu na p\u0159eprogramov\u00e1n\u00ed vynesl japonsk\u00e9mu biologovi \u0160injovi Jamanakovi v roce 2012 Nobelovu cenu.<\/p>\n\n\n\n

O \u010dty\u0159i roky pozd\u011bji v\u011bdci ze Salkova institutu testovali tuto techniku \u200b\u200bna \u017eiv\u00fdch my\u0161\u00edch trp\u00edc\u00edch p\u0159ed\u010dasn\u00fdm st\u00e1rnut\u00edm, onemocn\u011bn\u00edm podobn\u00fdm lidsk\u00e9 progerii. Cel\u00e9 my\u0161i vystavili t\u011bmto l\u00e1tk\u00e1m po kr\u00e1tkou dobu a zjistili, \u017ee n\u011bkter\u00e9 p\u0159e\u017eily d\u00e9le.<\/p>\n\n\n\n

Dal\u0161\u00edm krokem, nezbytn\u00fdm k tomu, aby bylo reprogramov\u00e1n\u00ed pova\u017eov\u00e1no za skute\u010dn\u00fd z\u00e1sah proti st\u00e1rnut\u00ed, bylo prok\u00e1zat, \u017ee by mohlo tak\u00e9 prodlou\u017eit \u017eivot zdrav\u00fdch my\u0161\u00ed.<\/p>\n\n\n\n

\"Je<\/a><\/figure>\n\n\n\n

\u201eKa\u017ed\u00fd ve v\u00fdzkumn\u00e9 komunit\u011b v\u00ed, \u017ee nejd\u016fle\u017eit\u011bj\u0161\u00edm experimentem je l\u00e9\u010dit norm\u00e1ln\u00ed my\u0161i a sledovat, zda prodlou\u017e\u00ed jejich \u017eivotnost nebo zlep\u0161\u00ed jejich celkov\u00e9 zdrav\u00ed,\u201c vysv\u011btluje Martin Borch Jensen, zakladatel Impetus Grants, organizace, kter\u00e1 financuje v\u00fdzkum st\u00e1rnut\u00ed.<\/p>\n\n\n\n

Kdy\u017e uplynulo n\u011bkolik let bez takov\u00e9ho v\u00fdsledku, za\u010daly se objevovat pochybnosti o \u00fa\u010dinnosti metody. Nad\u011bje na vytvo\u0159en\u00ed my\u0161\u00ed s mimo\u0159\u00e1dn\u011b dlouhou \u017eivotnost\u00ed za\u010daly sl\u00e1bnout. \u201eR\u016fzn\u00e9 t\u00fdmy se o tento experiment pokusily, ale v\u00fdsledky zat\u00edm nebyly pozitivn\u00ed,\u201c zd\u016fraz\u0148uje Alejandro Ocampo, biolog z Univerzity v Lausanne ve \u0160v\u00fdcarsku, kter\u00fd Salkovy p\u016fvodn\u00ed experimenty provedl.<\/p>\n\n\n\n

Nicm\u00e9n\u011b loni byla zve\u0159ejn\u011bna p\u0159edb\u011b\u017en\u00e1 zpr\u00e1va v\u00fdzkumn\u00e9ho t\u00fdmu, kter\u00fd studoval my\u0161i geneticky modifikovan\u00e9 od narozen\u00ed tak, aby produkovaly speci\u00e1ln\u00ed Yamanakovy faktory. Tento t\u00fdm, pracuj\u00edc\u00ed v N\u00e1rodn\u00edm institutu zdrav\u00ed a l\u00e9ka\u0159sk\u00e9ho v\u00fdzkumu, pozoroval trend sm\u011brem k del\u0161\u00ed \u017eivotnosti, ale zpr\u00e1va byla pova\u017eov\u00e1na za p\u0159edb\u011b\u017enou.<\/p>\n\n\n\n

Ve studii proveden\u00e9 spole\u010dnost\u00ed Rejuvenate Bio byla l\u00e9\u010dba pod\u00e1v\u00e1na pomoc\u00ed genov\u00e9 terapie \u2013 vir\u016f speci\u00e1ln\u011b navr\u017een\u00fdch k p\u0159enosu gen\u016f do bun\u011bk. Podle Noaha Davidsohna se d\u00edky tomu terapie podob\u00e1 l\u00e9\u010db\u011b, kterou by lid\u00e9 mohli podstoupit v re\u00e1ln\u00e9m sv\u011bt\u011b.<\/p>\n\n\n\n

My\u0161i \u017eij\u00ed ve voln\u00e9 p\u0159\u00edrod\u011b jen n\u011bkolik m\u011bs\u00edc\u016f, ale v laborato\u0159i mohou p\u0159e\u017e\u00edt dva nebo t\u0159i roky. My\u0161i v nejnov\u011bj\u0161\u00edm experimentu byly v dob\u011b pod\u00e1n\u00ed l\u00e9ku star\u00e9 ji\u017e 124 t\u00fddn\u016f, co\u017e znamenalo, \u017ee se bl\u00ed\u017eily ke konci sv\u00e9ho \u017eivota. Podle Noaha Davidsohna l\u00e9\u010den\u00e9 my\u0161i nejen\u017ee p\u0159e\u017eily v\u00fdrazn\u011b d\u00e9le, ale tak\u00e9 vykazovaly celkov\u011b lep\u0161\u00ed zdravotn\u00ed v\u00fdsledky.<\/p>\n\n\n\n

Rozsah pozorovan\u00e9ho prodlou\u017een\u00ed d\u00e9lky \u017eivota s\u00e1m o sob\u011b nen\u00ed bezprecedentn\u00ed. Program americk\u00e9 vl\u00e1dy, kter\u00fd testuje \u00fa\u010dinky l\u00e9k\u016f na dlouhov\u011bkost, uk\u00e1zal, \u017ee n\u011bkolik slou\u010denin, v\u010detn\u011b rapamycinu, m\u016f\u017ee prodlou\u017eit \u017eivot my\u0161\u00ed o 5 a\u017e 15 %.<\/p>\n\n\n\n

My\u0161i v\u0161ak mus\u00ed tyto l\u00e9ky u\u017e\u00edvat po zna\u010dnou \u010d\u00e1st sv\u00e9ho \u017eivota, zat\u00edmco p\u0159eprogramov\u00e1n\u00ed p\u0159in\u00e1\u0161\u00ed okam\u017eit\u00e9 v\u00fdsledky. \u201eJe to, jako byste mohli cel\u00fd \u017eivot ned\u011blat nic a st\u00e1le skl\u00edzet v\u00fdhody,\u201c zd\u016fraz\u0148uje Noah Davidsohn.<\/p>\n\n\n\n

Dal\u0161\u00ed krok: prodlou\u017een\u00ed lidsk\u00e9ho \u017eivota?<\/h2>\n\n\n\n

Spole\u010dnost Rejuvenate Bio v sou\u010dasn\u00e9 dob\u011b vyv\u00edj\u00ed l\u00e9ky pro genovou terapii pro psy a lidi, v\u010detn\u011b l\u00e9\u010dby srde\u010dn\u00edho selh\u00e1n\u00ed. Noah Davidsohn v\u011b\u0159\u00ed, \u017ee z dlouhodob\u00e9ho hlediska bude omlazen\u00ed u lid\u00ed mo\u017en\u00e9. \u201eKdybych v n\u011bj nev\u011b\u0159il, na tomto projektu bych nepracoval,\u201c zd\u016fraz\u0148uje.<\/p>\n\n\n\n

K p\u0159esn\u00e9mu ur\u010den\u00ed, jak\u00e9 zm\u011bny p\u0159eprogramov\u00e1n\u00ed gen\u016f u my\u0161\u00ed zp\u016fsobuje, je zapot\u0159eb\u00ed mnohem v\u00edce informac\u00ed a v\u011bdci tvrd\u00ed, \u017ee dal\u0161\u00ed skupiny budou muset experiment zopakovat, ne\u017e budou moci b\u00fdt p\u0159esv\u011bd\u010deny. \u201eR\u00e1d bych vid\u011bl, jak jin\u00fd t\u00fdm provede podobn\u00e9 studie a podrobn\u011bji prozkoum\u00e1, co se vlastn\u011b d\u011bje,\u201c \u0159\u00edk\u00e1 Borch Jensen.<\/p>\n\n\n\n

Podle Vittoria Sebastiana m\u016f\u017ee b\u00fdt \u00fa\u010dinek prodlou\u017een\u00ed \u017eivota, o kter\u00e9m informovala studie Rejuvenate Bio, zp\u016fsoben zm\u011bnami na \u00farovni jednoho org\u00e1nu nebo skupiny bun\u011bk, sp\u00ed\u0161e ne\u017e obecn\u00fdm omlazuj\u00edc\u00edm \u00fa\u010dinkem na \u00farovni my\u0161\u00ed. Mezi dal\u0161\u00ed nedostatky studie pat\u0159\u00ed, \u017ee Rejuvenate Bio p\u0159esn\u011b nedokumentovala, kter\u00e9 bu\u0148ky a kolik jich bylo genovou terapi\u00ed modifikov\u00e1no.<\/p>\n\n\n\n

V sou\u010dasn\u00e9 dob\u011b mnoho spole\u010dnost\u00ed pokra\u010duje ve sv\u00fdch projektech reprogramov\u00e1n\u00ed, ale vyb\u00edraj\u00ed rozpoznan\u00e9 patologie a zam\u011b\u0159uj\u00ed sv\u00e9 \u00fasil\u00ed na specifick\u00e9 org\u00e1ny.<\/p>\n\n\n\n

Spole\u010dnost Turn Bio, jej\u00edm\u017e spoluzakladatelem je Vittorio Sebastiano, douf\u00e1 nap\u0159\u00edklad, \u017ee dok\u00e1\u017ee lidem do poko\u017eky vpravit reprogramovac\u00ed faktory, kter\u00e9 by bojovaly proti vr\u00e1sk\u00e1m nebo stimulovaly r\u016fst vlas\u016f. Dal\u0161\u00ed spole\u010dnost, Life Biosciences, se chyst\u00e1 otestovat, zda reprogramov\u00e1n\u00ed o\u010dn\u00edch bun\u011bk m\u016f\u017ee vyl\u00e9\u010dit slepotu.<\/p>\n","protected":false},"excerpt":{"rendered":"Americk\u00fd startup tvrd\u00ed, \u017ee se mu poda\u0159ilo \u00fasp\u011b\u0161n\u011b \u201ep\u0159eprogramovat\u201c bu\u0148ky st\u00e1rnouc\u00edch my\u0161\u00ed, co\u017e jim umo\u017enilo \u017e\u00edt d\u00e9le. Tento v\u00fdsledek byl p\u0159edv\u00eddateln\u00fd a nazna\u010duje, \n [...]<\/a>","protected":false},"author":1,"featured_media":6326,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-6325","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"_links":{"self":[{"href":"https:\/\/fakt24.biz.ua\/index.php?rest_route=\/wp\/v2\/posts\/6325","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fakt24.biz.ua\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/fakt24.biz.ua\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/fakt24.biz.ua\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/fakt24.biz.ua\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=6325"}],"version-history":[{"count":1,"href":"https:\/\/fakt24.biz.ua\/index.php?rest_route=\/wp\/v2\/posts\/6325\/revisions"}],"predecessor-version":[{"id":6327,"href":"https:\/\/fakt24.biz.ua\/index.php?rest_route=\/wp\/v2\/posts\/6325\/revisions\/6327"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/fakt24.biz.ua\/index.php?rest_route=\/wp\/v2\/media\/6326"}],"wp:attachment":[{"href":"https:\/\/fakt24.biz.ua\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=6325"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/fakt24.biz.ua\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=6325"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/fakt24.biz.ua\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=6325"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}